What are the common adverse effects of tetracyclines?

Tetracyclines are a class of antibiotics known for their ability to treat a variety of infections. One notable adverse effect associated with their use is dental discoloration. This effect occurs particularly in children whose teeth are still developing, and it can result in permanent changes to the color of the teeth. Tetracyclines can bind to calcium in developing teeth, leading to stains that range from yellow to brown. This makes dental discoloration a significant consideration when prescribing tetracyclines to pediatric patients or to pregnant women, as the medication can affect the developing fetus as well.

While gastrointestinal upset is indeed a common side effect of many antibiotics, including tetracyclines, it is not as distinctive or characteristic as dental discoloration. Kidney damage can occur but is less frequently observed and usually relates to specific circumstances like pre-existing kidney disease or dehydration. Skin rashes can also occur, but again, dental discoloration remains a standout concern with tetracycline use due to its long-lasting implications. Thus, dental discoloration is typically highlighted as a key adverse effect of tetracyclines.