What condition is characterized by fever, fatigue, malaise, and a sloughing rash?

Stevens-Johnson Syndrome (SJS) is a serious condition that is often triggered by medications or infections. It is characterized by a combination of systemic symptoms such as fever, fatigue, and malaise, along with a severe skin manifestation that includes a sloughing rash. This rash is essentially a detachment of the epidermis from the dermis, leading to painful blistering and ulceration. The systemic symptoms like fever and malaise reflect the body’s response to the inflammatory process, which can also result in other complications.

In contrast, septic shock, while it does involve fever and malaise, is primarily a life-threatening condition caused by infection that leads to organ failure and is not specifically associated with a sloughing rash. Drug-induced lupus can present with a variety of systemic symptoms but does not typically feature a significant sloughing rash as seen in SJS. Erythema multiforme also involves a rash, but it tends to be less severe and doesn't usually result in the extensive epidermal detachment characteristic of Stevens-Johnson Syndrome. Therefore, the specific combination of fever, fatigue, malaise, and a sloughing rash is indicative of Stevens-Johnson Syndrome, making it the correct choice.