What is identified as the fourth generation cephalosporin?

Cefepime is recognized as a fourth-generation cephalosporin due to its enhanced spectrum of activity compared to earlier generations. Fourth-generation cephalosporins like cefepime are designed to be more effective against gram-negative bacteria, including those that are resistant to earlier cephalosporins. Additionally, cefepime possesses good activity against Pseudomonas aeruginosa, making it a valuable option in treating serious infections caused by resistant organisms.

Fourth-generation cephalosporins also have better stability against certain beta-lactamases, which are enzymes produced by bacteria that can inactivate various beta-lactam antibiotics. This increased stability allows cefepime to maintain efficacy in more complicated clinical situations.

In contrast, the other options represent earlier generations or have different spectrums of activity and uses: ceftazidime is a third-generation cephalosporin primarily used for pseudomonal infections; ceftriaxone is a third-generation agent well-suited for many common infections but not classified as fourth-generation; and cefotetan is a second-generation cephalosporin with specific effectiveness but less broad-spectrum activity compared to cefepime.