What is the primary method of administration for Vancomycin?

Vancomycin is primarily administered intravenously (IV) because of its pharmacokinetics and clinical applications. When given orally, vancomycin is poorly absorbed, which limits its systemic effect and makes it ineffective for treating systemic infections. In specific cases, such as the treatment of Clostridium difficile infection, oral administration may be used to target the infection in the gastrointestinal tract, but this is not the primary route for its general use.

Intramuscular administration is not commonly utilized for vancomycin due to the risk of irritation and pain at the injection site, which can complicate treatment. Additionally, this route does not provide adequate plasma concentrations necessary for effective treatment of serious infections.

Topical application is also not appropriate for vancomycin, as it is designed to treat systemic infections and typically requires higher concentrations that are best achieved through intravenous administration.

Thus, the intravenous route allows for optimal dosing and effectiveness of vancomycin, making it the primary method of administration for this important antimicrobial agent, especially in serious infections where rapid achievement of therapeutic levels in the bloodstream is crucial.