What is the treatment of choice for syphilis?

The treatment of choice for syphilis is Penicillin G, which is a highly effective antibiotic for this infection caused by the bacterium Treponema pallidum. Penicillin G is preferred due to its potency against the syphilis bacterium and its long half-life, allowing for effective treatment with fewer doses. Typically, it is administered through intramuscular injection, especially for the more severe or latent forms of the disease.

Penicillin G has a well-established track record in clinical studies and guidelines from organizations such as the Centers for Disease Control and Prevention (CDC), which endorse its use as the first-line treatment for all stages of syphilis. This is rooted in its ability to effectively eliminate the organism from the body, which is crucial in preventing complications associated with untreated syphilis, such as cardiovascular and neurological damage.

Other antibiotics listed, such as Ampicillin, Penicillin V, and Amoxicillin, are not considered the first-line choices for treating syphilis. While they may have some efficacy against certain bacteria, they do not match Penicillin G's effectiveness and are not recommended for syphilis treatment according to clinical guidelines.