What potential risk increases with the use of fluoroquinolones in older patients?

The risk that increases with the use of fluoroquinolones in older patients is tendon ruptures. Fluoroquinolones are a class of antibiotics that have been associated with an increased risk of tendon injuries, particularly in the Achilles tendon. This risk is heightened in older adults due to age-related degenerative changes in tendons and may also be exacerbated by factors such as concurrent use of corticosteroids, renal insufficiency, and existing tendon disorders.

In older patients, the decline in tendon elasticity and strength makes them more susceptible to injury, and fluoroquinolones can interfere with tendon repair mechanisms, leading to an increased likelihood of tendon ruptures. This is particularly concerning for the Achilles tendon, which is the most affected site. Health care providers need to be aware of this risk and carefully assess the necessity of prescribing fluoroquinolones to older populations, especially those with preexisting risk factors for tendon damage.