When initiating empiric treatment for a skin infection, which two types of infections should be covered?

The correct choice focuses on the need to provide coverage for the most common organisms responsible for skin infections, particularly Staphylococcus and Streptococcus species. These two bacteria are frequently implicated in soft tissue infections, including cellulitis, abscesses, and impetigo. Staphylococcus aureus, especially methicillin-resistant strains (MRSA), is a significant concern in skin infections, particularly in community settings. Streptococcus pyogenes is another major pathogen that often causes skin infections.

Covering both of these organisms in empiric therapy ensures broad-spectrum protection against the most likely pathogens before specific culture results are available. While Gram-negative bacteria and other organisms like E. coli can cause skin infections, they are not the primary focus in typical empirical treatment for initial skin infections, which tend to be dominated by Gram-positive cocci such as Staphylococcus and Streptococcus.

This highlights the importance of understanding the common microbial flora associated with skin infections when selecting appropriate empiric therapy.