Which adverse effect is associated with Chloramphenicol?

Chloramphenicol is an antibiotic that has several potential adverse effects, one of the most notable being grey baby syndrome. This condition occurs when newborns, particularly those who are premature or have low birth weight, are exposed to chloramphenicol because their livers are not fully developed and cannot adequately metabolize the drug. As a result, toxic levels can accumulate in the infant's body, leading to symptoms such as a greyish discoloration of the skin, respiratory problems, and hypothermia. This effect is particularly serious in neonates, making it crucial for clinicians to avoid the use of chloramphenicol in this population unless absolutely necessary.

Other possible adverse effects of chloramphenicol include blood dyscrasias like aplastic anemia and some liver toxicity issues, but those are less specific compared to the definitive grey baby syndrome associated with its use in infants. This association highlights the importance of careful medication management during pregnancy and infancy to avoid severe and potentially fatal outcomes.