Which of the following is a second generation cephalosporin used prior to GI surgery?

Cefotetan is indeed a second-generation cephalosporin that is often used as prophylaxis in the context of gastrointestinal surgery. Its broad spectrum of activity, particularly against Gram-negative bacteria, makes it suitable for this purpose. In surgeries involving the gastrointestinal tract, where there is a risk of contamination with anaerobic bacteria, cefotetan can provide effective coverage. Additionally, it has a good affinity for beta-lactamase-producing organisms that may be present.

Cefazolin, while a first-generation cephalosporin, is commonly used for surgical prophylaxis but is more effective against Gram-positive bacteria and has limited coverage for anaerobes. Cefalexin is primarily used for skin infections and is also a first-generation cephalosporin, thus not suitable for the needs of GI surgery. Cefepime, on the other hand, is a fourth-generation cephalosporin and therefore not categorized as a second-generation cephalosporin, making it less relevant when focusing specifically on second-generation options in this context.

Cefotetan's specific characteristics and efficacy against both aerobic and anaerobic bacteria present it as an ideal choice for reducing the risk of postoperative infections in GI surgery.