Which types of organisms are most commonly treated with natural penicillins?

Natural penicillins, primarily penicillin G and penicillin V, are most effective against various Gram-positive bacteria, including Streptococci and Enterococci. These organisms are part of the normal flora and can cause infections when they enter sterile sites in the body. Streptococcus species are known for causing illnesses such as strep throat, pneumonia, and skin infections, while Enterococcus species can lead to urinary tract infections and endocarditis.

The effectiveness of natural penicillins against these organisms is due to their ability to target the peptidoglycan cell wall of bacteria, which is prominent in Gram-positive species. This mechanism makes them highly effective against the enzymatic processes involved in the bacterial growth and cell division of such organisms.

In contrast, Staphylococcus aureus (often associated with Staph infections) can produce beta-lactamase, making it resistant to natural penicillins. Gram-negative bacilli generally have a more complex cell wall structure that inhibits the action of penicillin, which is why these types are typically treated with other classes of antibiotics that are more effective against Gram-negative bacteria.